ArticleMolecular psychiatry2026
Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The impact of electronic product use on children with tic disorders and ADHD, and management strategies: a review.Frontiers in psychiatry · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Physical activity and sedentary behavior are closely associated with neuropsychiatric diseases, while previous studies have mainly relied on self-reported data, which have been shown to be inconsistent with objectively measured metrics. Using data from 73,411 participants, objectively quantifying physical activity through energy expenditure and time allocation, we identified longitudinal associations between physical activity, sedentary behavior, and neuropsychiatric diseases using Cox proportional hazards models. Our findings indicated that moderate to vigorous physical activity energy expenditure showed the strongest protective effect on neuropsychiatric diseases (hazard ratios: 0.60-0.86, all FDR-Q < 0.001), while an increased proportion of sedentary time was identified as a risk factor for neuropsychiatric diseases (HRs: 1.05-1.54, FDR-Q < 0.05). Restricted cubic spline analyses demonstrated an L-shaped association linking physical activity and neuropsychiatric diseases and an inverted L-shaped relationship between sedentary behavior and dementia. Linear regression models further linked physical activity and sedentary behavior to cognitive function, physical function, and mental health. Key brain regions related to these behaviors included the lateral occipital cortex, cuneus, pallidum, and accumbens. Proteomics and metabolic analyses identified significant involvement of ITGAV protein and high-intensity lipoprotein. Structural equation modeling elucidated that inflammation and metabolism mediate the relationship between physical activity, sedentary behavior, and neuropsychiatric diseases. Overall, our study provides critical evidence of the link between physical activity, sedentary behavior, and neuropsychiatric diseases, shedding light on potential neurobiological mechanisms underlying these associations.
Indexed as
Identifiers
40975752What Socratic holds
Registered trials
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