Evidence map›Paper›PMID 40976137›Full record

ReviewBiomaterials2026

Unconventional bioprinting modalities for advanced tissue biofabrication.

I Deniz Derman, Myoung Hwan Kim, Medine Dogan Sarikaya, Yasar Ozer Yilmaz, Elisabeth Grace Aliftiras, Valeriya Stepanyants, Taino Rivera, Ibrahim T Ozbolat

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I Deniz DermanEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA; The Huck Institutes of Life Sciences, Penn State University, University Park, PA, 16802, USA.
Myoung Hwan KimThe Huck Institutes of Life Sciences, Penn State University, University Park, PA, 16802, USA; Biomedical Engineering Department, Penn State University, University Park, PA, 16802, USA.
Medine Dogan SarikayaEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA; The Huck Institutes of Life Sciences, Penn State University, University Park, PA, 16802, USA; Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.
Yasar Ozer YilmazEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA; The Huck Institutes of Life Sciences, Penn State University, University Park, PA, 16802, USA; Department of Nanoscience and Nanoengineering, Istanbul Technical University, Istanbul, Turkey.
Elisabeth Grace AliftirasBiomedical Engineering Department, Penn State University, University Park, PA, 16802, USA.
Valeriya StepanyantsBiomedical Engineering Department, Penn State University, University Park, PA, 16802, USA.
Taino RiveraBiomedical Engineering Department, Penn State University, University Park, PA, 16802, USA.
Ibrahim T OzbolatEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA; The Huck Institutes of Life Sciences, Penn State University, University Park, PA, 16802, USA; Biomedical Engineering Department, Penn State University, University Park, PA, 16802, USA; Materials Research Institute, Penn State University, University Park, PA, 16802, USA; Cancer Institute, Penn State University, University Park, PA, 16802, USA; Neurosurgery Department, Penn State University, University Park, PA, 16802, USA. Electronic address: ito1@psu.edu.

Funding

Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, Anna Karolina Palucka · 2019 to 2026
$23.1M
Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionR01DE028614 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI OZBOLAT, IBRAHIM · 2020 to 2024
$2.8M
3D Printing of Air: An Intangible Ink for Fabrication of Vascularized TissuesR01EB036245 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat, DINO J RAVNIC · 2024 to 2026
$1.7M
Leveraging Microsurgery and Bioprinting for Rapidly Oriented Vascularized Tissue EngineeringR01DE035200 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat, DINO J RAVNIC · 2025 to 2026
$1.3M
Developing in situ transcriptomics of a bioprinted follicular skin modelR21AR082668 · NIAMS · JACKSON LABORATORY · PI OH, JULIA, OZBOLAT, IBRAHIM · 2023 to 2023
$439k
NIAID NIH HHS U19 AI142733NIAMS NIH HHS R21 AR082668NIBIB NIH HHS R01 EB036245NIDCR NIH HHS R01 DE028614NIDCR NIH HHS R01 DE035200
6 · The paper itself

Abstract

Bioprinting has been widely used to fabricate three-dimensional constructs for various applications. However, conventional bioprinting modalities face challenges such as low resolution, poor repeatability, limited speed, and scalability constraints. To overcome these limitations, unconventional bioprinting modalities have been actively developed, utilizing electric fields, acoustic waves, magnetic forces, light, smart materials, and microfluidics to advance bioprinted tissues. This Review explores various unconventional bioprinting modalities, which significantly improve upon conventional counterparts to create complex, scalable heterogenous tissue constructs. In addition, emerging bioprinting methods, utilizing the principles of conventional or unconventional bioprinting modalities with new concepts integrated, such as embedded bioprinting, cryobioprinting, microgravity bioprinting and 4D bioprinting, were discussed. Key applications include functional tissue engineering, disease modeling, and organoid development, with future directions focusing on artificial intelligence-driven bioprinting, multimodal biofabrication, and intraoperative bioprinting to improve scalability and clinical translation. By integrating interdisciplinary innovations, unconventional bioprinting offers new opportunities to advance tissue biofabrication technologies.

Indexed as

BioprintingTissue EngineeringAnimalsHumansPrinting, Three-DimensionalTissue Scaffolds3D bioprintingMultimodal biofabricationUnconventional bioprinting

Identifiers

PMID40976137
PMCPMC12810354

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.