ReviewJournal of advanced research2026
The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Myocardial metabolic remodeling in human end-stage ischemic and non-ischemic cardiomyopathy.Journal of molecular and cellular cardiology · 2026Article
- Serum Homocysteine, Insulin Resistance, and Metabolic Risk Factors in Children and Adolescents with Obesity: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Energy Allocation Resilience and Endocrine Integration.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobally, the pathogenesis and progression of many human diseases are intimately associated with folate metabolism disorder. Emerging evidence from recent investigations has underscored the pivotal role of folate metabolism in cardiovascular homeostasis, particularly in the context of myocardial hypertrophy and heart failure (HF). Despite a wealth of pre-existing research, the underlying pathophysiological mechanisms remain not fully elucidated. AIM OF REVIEW: To deeply explore the complex interrelationships among folate metabolism, myocardial hypertrophy, and heart failure, this review systematically elucidates the impact of the folate-homocysteine (Hcy) axis on myocardial hypertrophy and HF progression, integrating both experimental evidence and clinical observations. This review also investigates how genetic variations, and environmental factors modulate folate metabolism, and their mechanistic links to the development of myocardial hypertrophy and heart failure. Additionally, the review explores epigenetic modifications and their intricate crosstalk with the folate-homocysteine-heart disease axis, providing a comprehensive framework of the underlying pathophysiology. Finally, it proposes potential therapeutic strategies targeting the folate-homocysteine axis for myocardial hypertrophy and HF. KEY SCIENTIFIC CONCEPTS OF REVIEW: Folate deficiency can lead to homocysteine accumulation, resulting in hyperhomocysteinemia (HHcy), which contributes to the development of myocardial hypertrophy and HF. Correcting the imbalance of the folate-homocysteine axis may interrupt this pathological cascade, positioning the folate-homocysteine axis as a potential target for the treatment of myocardial hypertrophy and HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.