ArticleBrain and behavior2025
Brain Microstructural Alterations in Children Post-COVID-19 Infection Through VBM, SBM, and Structural Covariance Network Analysis.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
Abstract
backgroundChildren represent a particularly vulnerable group to the long-term consequences of COVID-19 due to their ongoing neurodevelopment. This study aimed to identify transient and persistent structural alterations in children recovering from the infection by comparing pretreatment and posttreatment MRI scans and to evaluate differences in brain morphology and network organization relative to age- and sex-matched healthy controls.
methodsA retrospective cohort of 26 children aged 8-12 years with confirmed COVID-19 was compared to 26 healthy controls. All participants underwent high-resolution T1-weighted MRI on a 3T scanner using identical acquisition protocols. Standard VBM and SBM pipelines were applied to quantify cortical volume, thickness, and sulcal depth, followed by SCN analysis to construct correlation matrices based on gray matter metrics. Graph theoretic metrics, including clustering coefficients, eigenpath lengths, small-worldness, and global/local efficiencies, were computed under different network sparsity thresholds.
resultsCortical volume analyses revealed reductions in regions including the cingulate cortex, hippocampus, and superior temporal gyrus among children post-COVID-19, with within-group comparisons showing decreases in the left middle cingulate cortex (7.4-6.9 cm
conclusionsChildren recovering from COVID-19 may exhibit structural brain changes and network connectivity disruptions, some of which show partial resolution over time, whereas others persist. Long-term follow-up through comprehensive neuroimaging and clinical evaluation is necessary to clarify the potential impact on development.
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