Evidence map›Paper›PMID 40977108›Full record

ArticlePharmacogenomics

Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose.

Dan Petrovitch, Katie P Himes, Jason J Bischof, Robert S Braun, Jennifer L Brown, Isaiah C Eleda, Caroline E Freiermuth, Shaopeng Gu, O Trent Hall, Julie A Johnson and 8 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Dan PetrovitchDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, USA.ORCID 0000-0002-3414-9589
Katie P HimesDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, USA.ORCID 0009-0007-3443-130X
Jason J BischofDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Robert S BraunDepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.
Jennifer L BrownDepartment of Psychological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-6683-0053
Isaiah C EledaDepartment of Biological Sciences, Texas Tech University, Lubbock, TX, USA.
Caroline E FreiermuthDepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0001-9901-8419
Shaopeng GuDepartment of Biomedical Informatics, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
O Trent HallDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Julie A JohnsonClinical and Translational Science Institute, The Ohio State University, Columbus, OH, USA.
David F KisorDepartment of Pharmaceutical Sciences and Pharmacogenomics, College of Pharmacy, Natural and Health Sciences, Manchester University, Fort Wayne, IN, USA.
Joshua W LambertCollege of Nursing, University of Cincinnati, Cincinnati, OH, USA.
Michael S LyonsDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0002-4774-1899
Morgan V MaloneyDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, USA.
Brittany E PunchesDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0002-7546-1966
Emma QuarlesDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, USA.
Andrew K LittlefieldDepartment of Psychological Sciences, Texas Tech University, Lubbock, TX, USA.ORCID 0000-0002-4725-1152
Jon E SpragueThe Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green State University, Bowling Green, OH, USA.ORCID 0000-0003-0349-5072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFentanyl overdose is a public health crisis in the United States, as fentanyl was implicated in nearly 70% of drug overdose deaths in 2023. To provide insight into genetic factors that may influence risk of fentanyl overdose, we conducted a scoping review of associations between cytochrome P450 3A4 (CYP3A4) and 3A5 (CYP3A5) genetic variants and relevant phenotypes. AREAS COVERED: We searched databases through August 2025 for peer-reviewed studies of human subjects or postmortem samples, and integrated evidence from 64 genetic association studies that analyzed single nucleotide polymorphisms in EXPERT OPINION AND COMMENTARY: Evidence from 64 studies suggested that the no-function

Indexed as

Cytochrome P-450 CYP3ADrug OverdoseFentanylPolymorphism, Single NucleotideAnalgesics, OpioidHumansRisk FactorsAnalgesics, OpioidCYP3A4 protein, humanCYP3A5 protein, humanCytochrome P-450 CYP3AFentanylCYP3A4CYP3A5Fentanylopioid use disorderoverdosepharmacogeneticspharmacokineticsSNP

Identifiers

PMID40977108
PMCPMC12582058

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.