Evidence map›Paper›PMID 40977118›Full record

ArticleProteins2026

Metal-Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations.

Nilvea Ramalho de Oliveira, Andrei Santos Siqueira, Paulo Sérgio Alves Bueno, Evonnildo Costa Gonçalves, Juliano Zanette

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nilvea Ramalho de OliveiraInstituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil.
Andrei Santos SiqueiraLaboratório de Tecnologia Biomolecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0002-2397-7119
Paulo Sérgio Alves BuenoDepartamento de Bioquímica, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
Evonnildo Costa GonçalvesLaboratório de Tecnologia Biomolecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Juliano ZanetteInstituto de Ciências Biológicas, Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.509936/2020-00International Foundation for Science I-2-A/5350-2Organisation for the Prohibition of Chemical Weapons
6 · The paper itself

Abstract

Metallothioneins (MTLs) are small, cysteine-rich proteins known for their ability to bind metal ions and exhibit flexible, disordered structures. The structural and functional characteristics of metallothionein I (MTL-1) from Caenorhabditis elegans were investigated, focusing on its behavior in both metal free (MTL-1 Apo) and metal-bond states with Zn

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsMetallothioneinMetalsMetals, HeavyAmino Acid SequenceAnimalsBinding SitesCadmiumCopperIntrinsically Disordered ProteinsMercuryMolecular Dynamics SimulationProtein BindingProtein ConformationProtein StabilityCadmiumCaenorhabditis elegans ProteinsCopperIntrinsically Disordered ProteinsMercuryMetallothioneinMetalsMetals, HeavyZincAMBERmetalloproteinmolecular dynamic simulationstructural biologytridimensional protein

Identifiers

PMID40977118
PMCPMC12779199

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.