SynthesisBrain and behavior2025
Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.Brain and behavior · 2025Pooled it
- Early detection of Alzheimer's disease via multimodal MRI and machine learning.Frontiers in aging neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hippocampus is highly vulnerable in Alzheimer's disease (AD), with early microstructural changes potentially detectable via diffusion kurtosis imaging (DKI). Previous studies report promising DKI findings in AD, necessitating systematic evaluation. To compare hippocampal DKI metrics, particularly mean kurtosis (MK), between AD patients and healthy controls (HCs) and explore factors influencing these differences.
methodsFollowing PRISMA guidelines, PubMed, Scopus, Web of Science, and Embase were searched until November 2024. Two reviewers independently extracted hippocampal MK values. Risk of bias was evaluated using the Newcastle-Ottawa Scale. Meta-analysis employed random-effects models (STATA v17). Subgroup analyses (sex, age, magnetic resonance imaging [MRI] parameters) and sensitivity and trim-and-fill assessments were conducted. Standardized mean difference (SMD), I
resultsTen studies (215 AD patients, 217 HCs; mean age: 65-75 years) using 3.0 T MRI were included. Eight articles were included in the meta-analysis to compare MK between groups. AD patients exhibited significantly reduced bilateral hippocampal MK compared to HCs (left: SMD = -1.32, 95% confidence interval [95% CI] [-1.97 to -0.66]; right: SMD = -1.22 [-1.88 to -0.56]; both p < 0.001), indicating compromised microstructural complexity. Subgroup analyses revealed more pronounced MK reductions in studies with higher male ratios (>42%; left: SMD = -1.87; right: SMD = -1.91; p < 0.05). Age, echo time, repetition time, and diffusion directions did not significantly influence effect sizes. Sensitivity analyses confirmed robustness, and publication bias was detected, but trim-and-fill analyses revealed no missing studies.
conclusionReduced hippocampal MK in AD reflects microstructural degeneration, with sex-related differences in effect magnitude.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.