Evidence map›Paper›PMID 40977174›Full record

SynthesisClinical and experimental dental research2025

Curcumin Versus Corticosteroids for Symptomatic Oral Lichen Planus: A Systematic Review and Meta-Analysis.

Sadeq A Al-Maweri, Gamilah Al-Qadhi, Ahmed Yaseen Alqutaibi, Nadhem M Sallam, Mounzer Assad, Mahfoudh A Abdulghani, Marwan Mansoor Ali Mohammed

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sadeq A Al-MaweriCollege of Dental Medicine, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0003-4932-1377
Gamilah Al-QadhiDepartment of Basic Dental Sciences, Faculty of Dentistry, University of Science and Technology, Aden, Yemen.
Ahmed Yaseen AlqutaibiDepartment of Prosthodontics, College of Dentistry, Taibah University, Medina, Saudi Arabia.ORCID 0000-0001-6536-8269
Nadhem M SallamDepartment of Paediatric and Preventive Dentistry, Faculty of Dentistry, Thamar University, Dhamar, Yemen.
Mounzer AssadDepartment of Oral Surgery, Faculty of Dentistry, Tishreen University, Lattakia, Syria.
Mahfoudh A AbdulghaniPharmacology Department, International Medical School, Management and Science University, Shah Alam, Selangore, Malaysia.
Marwan Mansoor Ali MohammedDepartment of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.ORCID 0000-0002-7101-1239

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

objectivesThe management of oral lichen planus (OLP) is challenging, with no definitive cure available. This systematic review and meta-analysis aimed to assess the efficacy of curcumin in managing OLP. MATERIAL AND

methodsA comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted for relevant clinical trials published up to March 31, 2025. All clinical trials comparing the efficacy of curcumin to corticosteroids were included. A meta-analysis was conducted on studies with available numerical data to assess the efficacy of curcumin relative to the control group.

resultsEleven clinical trials, involving 499 OLP patients, were included in this review, with nine studies were incorporated into the meta-analysis. All studies reported curcumin to be efficacious in alleviating the signs and symptoms of OLP. Pooled data showed significantly better efficacy of curcumin in reducing pain at 1 week (SMD, -0.70; 95% CI, -1.33, -0.07; p = 0.03; I

conclusionsThe available evidence suggests that curcumin has promising effects in managing OLP. However, due to methodological limitations, including significant heterogeneity among the studies and a high risk of bias in most of them, further well-designed studies with adequate follow-up periods are needed.

Indexed as

Adrenal Cortex HormonesCurcuminLichen Planus, OralHumansTreatment OutcomeAdrenal Cortex HormonesCurcumincorticosteroidscurcuminefficacyoral lichen planussystematic review

Identifiers

PMID40977174
PMCPMC12451056

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.