Evidence map›Paper›PMID 40977522›Full record

ArticleJournal of cellular and molecular medicine2025

Reduced FGF9 Leads to Kidney Injury Through Regulating Renal Tubular Epithelial Cell EMT in Diabetes.

Wen-Qing Chen, Chengyang Sun, Xiaotan Zhang, Xunjia Ye, Yuzhen Liu, Hui-di Wang, Lichao Liu, Danrui Li, Jingyun Wang, Meiting Shi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wen-Qing ChenThe First Affiliated Hospital of Jinan University, School of Medicine, Jinan University, Guangzhou, China.
Chengyang SunInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Xiaotan ZhangThe First Affiliated Hospital of Jinan University, School of Medicine, Jinan University, Guangzhou, China.
Xunjia YeInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Yuzhen LiuInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Hui-di WangThe First Affiliated Hospital of Jinan University, School of Medicine, Jinan University, Guangzhou, China.
Lichao LiuInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Danrui LiThe First Affiliated Hospital of Jinan University, School of Medicine, Jinan University, Guangzhou, China.
Jingyun WangFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology, Pneumology), University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Meiting ShiInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Fang YangThe First Affiliated Hospital of Jinan University, School of Medicine, Jinan University, Guangzhou, China.
Christoph ReichetzederFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology, Pneumology), University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Berthold HocherFifth Department of Medicine (Nephrology/Endocrinology/Rheumatology, Pneumology), University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Xuesong YangInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.
Baozhang GuanThe First Affiliated Hospital of Jinan University, School of Medicine, Jinan University, Guangzhou, China.
Guang WangInternational Joint Laboratory for Embryonic Development and Prenatal Medicine, Division of Histology and Embryology, School of Medicine, Jinan University, Guangzhou, China.ORCID 0000-0001-7595-2880

Funding

National Natural Science Foundation of China 32170825the Science and Technology Program of Guangzhou 202201020068
6 · The paper itself

Abstract

Diabetic nephropathy (DN) stands out as one of the most prevalent and severe chronic microvascular complications associated with diabetes, serving as the primary cause of end-stage renal disease (ESRD) in developed and developing countries. However, the precise pathogenesis remains incompletely elucidated. Our study suggests FGF9 as a key gene in DN using bioinformatics analysis. We found a negative correlation between FGF9 and serum creatinine and a positive one with glomerular filtration rate in DN patients. FGF9 expression was lower in DN patients' glomeruli and tubules. High FGFR expression in renal tubular cells, along with increased α-SMA and TGF-β1, indicates a role for the epithelial-to-mesenchymal transition (EMT) process in diabetes mellitus (DM) mouse renal tubular epithelial cells. Subsequently, we modulated FGF9 in HK2 cells under different glucose conditions. The genes regulated by FGF9 were identified (LOX, HIF1α, THBS1, TGFβ2 and ITGβ1) through RNA sequencing analysis. It was suggested that FGF9 promotes the development of renal EMT probably through regulating these genes. Overall, FGF9 could be a biomarker and therapeutic target for DN.

Indexed as

Diabetic NephropathiesEpithelial CellsEpithelial-Mesenchymal TransitionFibroblast Growth Factor 9Kidney TubulesAnimalsBiomarkersCell LineFemaleGene Expression RegulationHumansMaleMiceBiomarkersFGF9 protein, humanFibroblast Growth Factor 9diabetic nephropathyepithelial‐to‐mesenchymal transitionfibroblast growth factor 9renal fibrosis

Identifiers

PMID40977522
PMCPMC12451398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.