Evidence map›Paper›PMID 40977612›Full record

Trial reportJournal of the International Society of Sports Nutrition2025

Performance-enhancing effects of caffeine and L-Theanine among Iranian elite wrestlers: a focus on cognitive and specific physical performance.

Rouzbeh Razazan, Mohammad Hemmatinafar, Babak Imanian, Nima Jahaniboushehri, Rasoul Rezaei, Gholamhossein Nazemzadegan

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rouzbeh RazazanShiraz University, Department of Sport Science, Faculty of Education and Psychology, Shiraz, Iran.
Mohammad HemmatinafarShiraz University, Department of Sport Science, Faculty of Education and Psychology, Shiraz, Iran.ORCID 0000-0001-7585-7592
Babak ImanianShiraz University, Department of Sport Science, Faculty of Education and Psychology, Shiraz, Iran.
Nima JahaniboushehriShiraz University, Department of Sport Science, Faculty of Education and Psychology, Shiraz, Iran.
Rasoul RezaeiShiraz University, Department of Sport Science, Faculty of Education and Psychology, Shiraz, Iran.
Gholamhossein NazemzadeganShiraz University, Department of Sport Science, Faculty of Education and Psychology, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaffeine is a well-known ergogenic aid that can enhance physical and cognitive performance. However, it often induces side effects, such as anxiety and overstimulation, which can be problematic in high-pressure sports like wrestling. L-theanine, a non-stimulant amino acid found in tea, may help mitigate these effects by promoting a calm yet focused mental state. This study aimed to investigate the acute effects of caffeine, L-theanine, and their combination on physical performance, cognitive function, and anxiety in elite male wrestlers.

methodsIn a double-blind, placebo-controlled, crossover design, 12 elite male wrestlers (21.8 ± 2.1 years) completed four test sessions under randomized conditions: placebo (PLA), caffeine (CAF; 3 mg/kg), L-theanine (THE; 3 mg/kg), and caffeine + L-theanine (CAF+THE; 3 mg/kg each). After 60 minutes, athletes performed the wall-squat test, vertical jump height (VJH), medicine ball throw (MBT), handgrip strength, and the Specific Wrestling Fitness Test (SWFT). Cognitive function was assessed pre- and post-SWFT using a computerized Stroop test. Anxiety was assessed using the State-Trait Anxiety Inventory (STAI), and side effects were recorded.

resultsCAF+THE outperformed PLA in wall-squat time (

conclusionCAF+THE (3 mg/kg each) enhances elite wrestlers' strength, endurance, cognitive speed, and accuracy while reducing anxiety and physiological side effects commonly associated with caffeine alone. This combination represents a safe, practical supplement strategy for combat sports athletes who must maintain explosive performance and mental control under stress. Coaches are encouraged to trial CAF+THE protocols during training to personalize timing and dosage.

Indexed as

Athletic PerformanceCaffeineCognitionGlutamatesPerformance-Enhancing SubstancesWrestlingAnxietyAthletesCross-Over StudiesDouble-Blind MethodHand StrengthHumansIranMaleYoung AdultCaffeineGlutamatesPerformance-Enhancing Substancestheanineanxiety modulation in athletesCaffeine–l-theanine co-supplementationcognitive and physical performanceiranian elite wrestlersspecific wrestling fitness test

Identifiers

PMID40977612
PMCPMC12456047

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.