ArticleInquiry : a journal of medical care organization, provision and financing
The New WHO Cut-off Point for Defining High-altitude Anemia may be Inadequate.
Article in Inquiry : a journal of medical care organization, provision and financing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Beyond deficiency: The emerging health risks of excess iron.Science progressArticle
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
introductionPeru carries a high burden of childhood anemia, particularly in high-altitude regions where hemoglobin (Hb) adjustment for altitude is recommended. This study aimed to evaluate whether the proportion of anemia attributable to iron deficiency (ID), inflammation, and red blood cell indices varies by altitude in children, using different diagnostic criteria.
methodsWe conducted a cross-sectional study of 280 children aged 6 to 72 months residing in Arequipa, Peru at altitudes ranging from 9 to 4310 m above sea level. Venous blood samples were collected to assess Hb, complete blood count, and serum biomarkers of iron status and inflammation. Spearman's rank correlation was used to examine relationships between altitude and hematologic or biochemical parameters. Logistic regression models evaluated associations between altitude, Hb concentration, and anemia prevalence, defined with and without altitude adjustment.
resultsAnemia prevalence increased from 12% to 31% after applying altitude-adjusted Hb thresholds. At mid-altitudes (1000-<3000 m), prevalence rose from 8.3% to 43.8% (
conclusionThese findings suggest that altitude-adjusted Hb cutoffs may overestimate anemia prevalence and lead to misclassification of IDA in high-altitude pediatric populations.
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