Evidence map›Paper›PMID 40977672›Full record

ArticleWorld journal of gastrointestinal oncology2025

Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates

Yi-Jia Chen, Cheng Peng, Li-Wei Wang, Jia-Xin Chai, Jian-Dong Wang, Qi-Bin He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi-Jia ChenDepartment of Gastroenterology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, Jiangsu Province, China.
Cheng PengDepartment of Gastroenterology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, Jiangsu Province, China.
Li-Wei WangDepartment of Gastroenterology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, Jiangsu Province, China.
Jia-Xin ChaiDepartment of Pathology, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing 210002, Jiangsu Province, China.
Jian-Dong WangDepartment of Pathology, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing 210002, Jiangsu Province, China.
Qi-Bin HeDepartment of Gastroenterology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, Jiangsu Province, China. 13770936117@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUncoupling protein 1 (

aimTo investigate the expression and function of UCP1 in gastric cancer (GC).

methodsUCP1 protein expression in 211 GC tissues was examined using immunohistochemistry. Bisulfite sequencing PCR (BSP) was used to detect the methylation status of the

resultsLoss of UCP1 was significantly associated with gender, poor differentiation, and advanced TNM stage of GC. Hypermethylation of

conclusionUCP1 downregulation in GC through promoter hypermethylation is related to the progression of GC, indicating that

Indexed as

Gastric cancerHypermethylationRap1 signalingUncoupling protein 1

Identifiers

PMID40977672
PMCPMC12444320

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.