Evidence map›Paper›PMID 40977739›Full record

ArticleFrontiers in immunology2025

Identifying pyroptosis-hub genes and immune infiltration in neonatal hypoxic-ischemic brain injury.

Chi Qin, Yue Li, Meiying Cheng, Huixian Li, Ronghao Mu, Jian Jin, Bohao Zhang, Xin Zhao, Xiaoan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chi Qin *Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yue Li *Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Meiying ChengDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huixian LiDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ronghao MuDepartment of Child Developmental Behavior, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jian JinDepartment of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bohao ZhangDepartment of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xin ZhaoDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoan ZhangDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal brain injury and neurodevelopmental disorders. Pyroptosis, an inflammatory programmed cell death, may offer new therapeutic targets for HIE by modulating cytokine expression and related pathways. This study aims to identify HIE-associated pyroptosis genes and explore potential drugs and molecular mechanisms. Methods: The gene microarray data of hypoxic-ischemic brain damage (HIBD) were obtained from the Gene Expression Omnibus (GEO) database. The Limma package was used to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was performed to find significant expression modules. GO and KEGG analyses were carried out for the pathway enrichment of DEGs, as well as protein-protein interaction (PPI) network analysis were subsequently conducted. Cytohubba software was employed to identify hub genes among DEGs. A random forest (RF) model assessed the pyroptosis-related genes, examining their diagnostic performance. Potential therapeutic drugs or compounds targeting the hub genes were screened through DSigDB, and their binding scores and affinities were evaluated by molecular docking. Results: 96 DEGs with HIBD were identified in our result, including 89 up-regulated genes and 7 down-regulated genes. GO and KEGG results indicated that these DEGs were mostly enriched in Cytokine-cytokine receptor interaction, IL-17 signaling pathway and TNF signaling pathway. Using Cytoscape software and WGCNA-related modules, we identified three hub genes- Conclusion:

Indexed as

Hypoxia-Ischemia, BrainPyroptosisComputational BiologyDatabases, GeneticGene Expression ProfilingGene Regulatory NetworksHumansInfant, NewbornMolecular Docking SimulationProtein Interaction MapsToll-Like Receptor 2TranscriptomeToll-Like Receptor 2bioinformaticshypoxic-ischemic brain damageimmune infiltrationmachine learningpyroptosis

Identifiers

PMID40977739
PMCPMC12446038

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.