Evidence map›Paper›PMID 40977839›Full record

ReviewMaterials today. Bio2025

Breaking the vicious cycle: Multifunctional nanomaterials targeting Tumor metabolic reprogramming to overcome T cell exhaustion and bone repair failure in bone tumors.

Shijin Guo, Ziyi Yan, Yuling Huang, Xueneng Hu, Huaiyuan Zhang, Yu Wang, Tinglin Zhang, Huifen Qiang, Minghao Xue, Jie Gao and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. CaMaterials today. Bio · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shijin GuoDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Ziyi YanDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Yuling HuangDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Xueneng HuDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Huaiyuan ZhangDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Yu WangDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
Tinglin ZhangChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Huifen QiangChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Minghao XueCollege of Life Science, Mudanjiang Medical University, Mudanjiang, 157011, China.
Jie GaoChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Zuochong YuDepartment of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tumors establish a self-perpetuating vicious cycle wherein metabolic reprogramming (

Indexed as

Aerobic glycolysisBone damageBone Tumor microenvironmentGlutamine metabolismMetabolic reprogrammingNanomaterialsT cell exhaustion

Identifiers

PMID40977839
PMCPMC12448039

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.