Evidence map›Paper›PMID 40977851›Full record

ArticleJournal of cell communication and signaling2025

Tri-domain proteins 27 alleviates ischemia-reperfusion injury-induced acute kidney injury by promoting Gli-like transcription factor 1 expression via the inhibition of polycomb repressive complex 2 activity.

Chongxiang Xiong, Haishan Chen, Baoting Su, Li Zhang, Jingxiang Hu, Qiaowen Wang, Shougang Zhuang

Abstract read
In one paragraph

Article in Journal of cell communication and signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chongxiang XiongDepartment of Nephrology The First Dongguan Affiliated Hospital of Guangdong Medical University Dongguan Guangdong Province China.
Haishan ChenDepartment of Nephrology The First Dongguan Affiliated Hospital of Guangdong Medical University Dongguan Guangdong Province China.
Baoting SuDepartment of Nephrology The First Dongguan Affiliated Hospital of Guangdong Medical University Dongguan Guangdong Province China.
Li ZhangDepartment of Nephrology The First Dongguan Affiliated Hospital of Guangdong Medical University Dongguan Guangdong Province China.
Jingxiang HuDepartment of Nephrology The First Dongguan Affiliated Hospital of Guangdong Medical University Dongguan Guangdong Province China.
Qiaowen WangDepartment of Nephrology The First Dongguan Affiliated Hospital of Guangdong Medical University Dongguan Guangdong Province China.
Shougang ZhuangDepartment of Medicine Rhode Island Hospital and Brown University School of Medicine Providence Rhode Island USA.ORCID https://orcid.org/0009-0003-7743-3971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dedifferentiated renal tubular epithelial cell (RTEC) proliferation contributes to renal repair following acute kidney injury (AKI) induced by renal ischemia-reperfusion (I/R) injury (RIRI). However, the fundamental mechanism underlying RTEC dedifferentiation remains unclear. An animal model of RIRI-induced AKI was established using I/R, and H

Indexed as

acute kidney injuryGLIS1renal ischemia and reperfusion injuryrenal tubular epithelial cell dedifferentiationTRIM27

Identifiers

PMID40977851
PMCPMC12444411

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.