ArticlePlastic and reconstructive surgery. Global open2025
Effect of Platelet-rich Plasma and Brief Electrical Stimulation Following Facial Nerve Neurorrhaphy in a Rat Model.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With ongoing investigations to improve facial nerve recovery after injury, brief electrical stimulation (BES) and platelet-rich plasma (PRP) application have become promising modalities. The usage of combined modalities has not yet been investigated. We aimed to evaluate differences in facial nerve regeneration between rats receiving BES (group 1) and rats receiving BES plus PRP (group 2) following transection and primary neurorrhaphy. Methods: This was a prospective randomized animal study of 2 groups of 6 rats that underwent facial nerve transection and repair at the main trunk of the nerve. Both groups received BES on postoperative day 0 for 1 hour using an implantable stimulation device, with group 2 additionally receiving concurrent PRP. The primary measure of whisker amplitude was recorded from 2 to 8 weeks postoperatively. Results: At week 2, the average whisker amplitude for groups 1 and 2 was 6.5 and 2.0 degrees, respectively. At week 4, group 1 remained unchanged at 6.1 degrees, whereas group 2 improved to 10.1 degrees. By 6 weeks, average amplitudes were 8.2 and 14.0 degrees, respectively. By week 8, measures were 9.8 and 16.7 degrees, respectively. All results were statistically significant ( Conclusions: Application of BES and PRP following neurorrhaphy in a rat model yields a greater effect than BES alone in expediting facial nerve recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.