ReviewAmerican journal of clinical and experimental immunology2025
The immunomodulatory role of seminal plasma in endometrial receptivity and embryo implantation.
Review in American journal of clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Differential Impact of the Endometrial Immune Environment in Fresh Versus Frozen Embryo Transfer.Cells · 2026Trial
- Current Evidence on IL-17 and IL-(12)/23 Inhibitor Safety during Pregnancy in Psoriasis: A Call for Harmonized Data Collection.Acta dermato-venereologica · 2026Article
- A mouse model of Zika virus sexual transmission reveals a limited transmission window shorter than viral RNA persistence in semen.PLoS pathogens · 2026Article
- Review
- Prostatitis-Related Male Infertility: From Inflammation and Dysbiosis to Sperm DNA Damage.Diagnostics (Basel, Switzerland) · 2026Review
- Human seminal plasma suppresses neutrophil antimicrobial functions and promotes bacterial survival.Frontiers in immunology · 2026Article
- Article
- Regulatory T cells in pregnancy disorders: a multi-dimensional framework for biomarkers and therapeutic strategies.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful implantation and pregnancy rely on complex interactions between the embryo and the maternal reproductive tract. Seminal plasma components, including proteins, cytokines, and growth factors, are pivotal in enhancing endometrial receptivity and inducing maternal immune tolerance to the developing conceptus. Exposure to seminal plasma facilitates pathogen clearance, supports embryo development, and modulates immune responses by altering the endometrial transcriptome and promoting regulatory T cell (Treg) expansion. Proteomic studies have identified seminal plasma factors involved in these processes. Changes in the immunomodulatory components of seminal plasma can diminish its positive effects on the endometrium, potentially resulting in reduced fertility and increased risk of adverse pregnancy outcomes. This review explores how seminal plasma influences maternal immune responses and highlights the clinical implications, particularly its potential to improve outcomes in assisted reproductive technologies (ART) like in vitro fertilization (IVF). Understanding the molecular dialogue between seminal plasma and the endometrium may lead to new strategies for enhancing fertility and promoting healthy pregnancy.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.