ReviewFrontiers in nutrition2025
Effects of prenatal iron deficiency on neurological development and related disorders in offspring.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Permissive Parenting Style and Anemia Are Associated with Developmental Delays Among Under-Five Children in Bandung District, West Java, Indonesia.Children (Basel, Switzerland) · 2026Article
- Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fetal origins of adult disease hypothesis proposes that a variety of adverse stimuli during critical development stages can impair the structure and function of fetal organs, thereby increasing the risk of disease later in life. Iron affects fetal growth and development by facilitating oxygen and electron transport and by serving as a cofactor for enzymes that affect enzyme activity. Fetal iron deficiency (ID) can result from various factors during pregnancy, including inadequate maternal iron intake, maternal obesity, diabetes, smoking, prenatal stress, and prenatal alcohol exposure. These conditions disrupt fetal brain development and are associated with neurological disorders in offspring, such as cognitive impairment, anxiety, depression, schizophrenia, and autism. However, the mechanisms by which maternal iron deficiency leads to abnormal neurological development, as well as cognitive impairment and psychiatric disorders in the offspring, remain unknown. In this review, we summarize the causes of prenatal iron deficiency, the effects of iron deficiency on brain development and behavioral phenotypes, and the potential molecular mechanisms.
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