ArticleiScience2025
Evolutionary adaptations of TRPA1 thermosensitivity and skin thermoregulation in vertebrates.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene-Edited Xenopus Tadpoles.Journal of pineal research · 2026Article
- A Thermo-Sensitive Molecular Switch:International journal of molecular sciences · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin pigmentation contributes to thermoregulation in ectothermic vertebrates, while homeotherms rely on insulation such as feathers, fur, or blubber. Heat-sensing in vertebrates largely depends on transient receptor potential (TRP) channels, with TRPA1 showing evolutionary shifts in sensitivity. The exploration of a role for TRP channels in skin physiology has largely focused on human pigmentation and overlooked the evolution of different thermoregulatory structures in the integument of distinct vertebrates. We investigated heat-induced skin darkening in the ectotherm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.