Evidence map›Paper›PMID 40978168›Full record

ArticleThe journal of allergy and clinical immunology. Global2025

Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis.

Yuki Sonoda, Yoshimasa Imoto, Ayako Maegawa, Anna Shimizu, Masanori Kidoguchi, Rikako Gozawa, Keisuke Koyama, Naoto Adachi, Taiyo Morikawa, Yuto Miyazaki and 5 more

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Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuki SonodaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yoshimasa ImotoDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Ayako MaegawaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Anna ShimizuDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Masanori KidoguchiDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Rikako GozawaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Keisuke KoyamaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Naoto AdachiDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Taiyo MorikawaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yuto MiyazakiDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takahiro TokunagaDepartment of Otorhinolaryngology, Shinseikai Toyama Hospital, Toyama, Japan.
Masafumi SakashitaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Shigeharu UekiDepartment of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Takechiyo YamadaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Akita, Akita, Japan.
Shigeharu FujiedaDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Eosinophilic chronic rhinosinusitis (ECRS) is characterized by intense eosinophil infiltration in nasal polyps (NPs), related to asthma comorbidity and elevated circulating eosinophil levels. The mechanism by which these systemic components affect type 2 inflammation in NPs is poorly understood. Objective: We sought to evaluate the relationship between lung function and eosinophilia in chronic rhinosinusitis and assess whether ECRS reflects lower airway involvement and systemic eosinophilic inflammation. Methods: We examined 198 patients with chronic rhinosinusitis. Lung function was assessed preoperatively using spirometry and fractional exhaled nitric oxide (Feno). Patients were classified into ECRS and non-ECRS groups on the basis of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis score, and patients with odontogenic maxillary sinusitis (OMS) were included for comparison. mRNA expressions of inflammatory cytokines in NPs were measured by quantitative real-time PCR. Results: FEV Conclusions: Respiratory function was significantly lower in patients with ECRS without an asthma diagnosis compared with non-ECRS and OMS groups. Enhanced eosinophilic inflammation in NPs may affect the lower airways, suggesting an eosinophilic united airway disease.

Indexed as

asthmaEosinophilic chronic rhinosinusitiseosinophilslung functionnasal polypstype 2 cytokines

Identifiers

PMID40978168
PMCPMC12446768

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.