Krüppel-like factor 4 regulates cellular proliferation and differentiation in human bone marrow-derived mesenchymal stem cells.

Kenichi Miyamoto, Satoru Miyagi, Rintaro Yoshikawa, Yuichi Michikawa, Yumi Matsuzaki

Abstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenichi MiyamotoDepartment of Life Science, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo City, Shimane, 693-8501, Japan.

Satoru MiyagiDepartment of Life Science, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo City, Shimane, 693-8501, Japan.

Rintaro YoshikawaDepartment of Life Science, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo City, Shimane, 693-8501, Japan.

Yuichi MichikawaHuman Resources and Networking Section, Department of Co-creation Promotion, Institute of Radiological Science, National Institute for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage-ku, Chiba, 263-8555, Japan.

Yumi MatsuzakiDepartment of Life Science, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo City, Shimane, 693-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) form one of the types of adult stem cell which have the capacity to self-renew, and the multipotentiality for osteogenic, chondrogenic and adipogenic differentiation and immune modulation. Consequently, MSCs are an attractive cell source for regenerative medicine and therapy for inflammatory disease. However, biological criteria to ensure any particular MSCs are "stem cells" have not been clarified. Previously, we reported that MSCs isolated from a single CD90/CD271 double-positive cell in human bone marrow have high colony-forming capacity and tri-lineage differentiation potential

Indexed as

DifferentiationKrüppel-like factor 4Mesenchymal stem cellsProliferation

Identifiers

PMID40978197

DOI10.1016/j.bbrep.2025.102241

PMCPMC12447919

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.