ArticleEcology and evolution2025
Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation.
Article in Ecology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Integrated multi-omics analysis reveals a gut microbiota-tryptophan metabolism axis contributes to sex differences in a β-aminopropionitrile-induced aortic dissection mouse model.Biology of sex differences · 2026Article
- Seasonal Plasticity in Tryptophan Metabolism Provides New Insights Into Physiological Adaptation in Snake Hibernation.Ecology and evolution · 2025Article
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Authors and funding
11 authors.
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Abstract
Hibernation is a common behavioral strategy for snakes to cope with extreme environments. This phenomenon has raised important scientific questions regarding its physiological adaptation mechanisms. Although tryptophan and its metabolites have been widel y studied for their roles in various physiological processes in animals-including immune regulation, metabolic homeostasis, and circadian rhythms-the impact of snake hibernation on tryptophan metabolism remains unexplored. In the present study, an integrated multi-omics approach that combines targeted metabolomics, transcriptomics, and microbiome was used to reveal the tryptophan metabolism mechanisms in active and hibernating snakes. Our results revealed that the higher gut indole concentrations observed in active snakes indicate a greater reliance on microbial pathways in their tryptophan metabolism. Correlation analyses between gut microbiota and indole levels further identified specific bacterial genera-
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