Evidence map›Paper›PMID 40978632›Full record

ArticleBioinformation2025

Analysis of genomic traits of oral and laryngeal cancer: A comparative study.

Megha Prabhakar, Meenakshi Garg, Jakkula Kishore, Subhankar Sutradhar, Subhash Chandra Pankaj, Jyotsna Seth, Miral Mehta, Bhumika J Patel

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Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Megha PrabhakarDepartment of ENT, SRVS Medical College, Shivpuri, Madhya Pradesh, India.
Meenakshi GargDepartment of ENT, SRVS Medical College, Shivpuri, Madhya Pradesh, India.
Jakkula KishoreDeaprtment of General Surgery, KIMS hospital Visakhapatnam, Andhra Pradesh, India.
Subhankar SutradharDepartment of Public health dentistry Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, India.
Subhash Chandra PankajDepartment of Prosthodontics and Implantology, Government Dental College, Raipur, Chhattisgarh, India.
Jyotsna SethDepartment of Prosthodontics, Seema Dental College and Hospital, Rishikesh, Uttarakhand, India.
Miral MehtaDepartment of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India.
Bhumika J PatelDepartment of Dentistry, Howard University, College of Dentistry, Washington DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral and laryngeal cancers exhibit overlapping clinical features but distinct genomic profiles. In a study of 60 Head and neck squamous cell carcinomas(HNSCC) cases (30 OSCC, 30 LSCC), NGS revealed TP53 mutations in 70% of oral squamous cell carcinoma (OSCC) and 83% of laryngeal squamous cell carcinoma (LSCC). CDKN2A alterations were more common in OSCC (40%) than LSCC (20%), while PIK3CA mutations were higher in LSCC (30%). NOTCH1 mutations were more frequent in OSCC (27%) than LSCC (10%). Pathway analysis showed disruptions in p53 and PI3K-Akt, with stronger enrichment in LSCC (ES: 3.42). The results suggest site-specific tumor biology influencing therapeutic targets. Molecular profiling is crucial for precision treatment in head and neck cancers.

Indexed as

comparative oncologygenomic profilinglaryngeal cancernext-generation sequencingOral cancerPI3K-akt pathwayTP53

Identifiers

PMID40978632
PMCPMC12449543

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.