Fetal loss in women exposed to cigarette smoke in-utero.

Talita Honorato-Rzeszewicz, Annemieke Hoek, Maaike L Haadsma, Henk Groen

Abstract read

In one paragraph

Article in Preventive medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Talita Honorato-RzeszewiczUniversity of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, the Netherlands.

Annemieke HoekUniversity of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, the Netherlands.

Maaike L HaadsmaDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.

Henk GroenUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Animal studies have shown meiotic errors in follicles after exposure to cigarette smoke in-utero. Epidemiological studies investigating effects of in-utero smoke exposure on fetal loss in humans show inconclusive results and did not control for extraneous smoke exposure. We aimed to investigate the association between cigarette smoke exposure in-utero and risk of fetal loss, independent of active or second-hand smoking. Methods: We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort ( Results: In 7033 women in-utero smoke exposure and fetal loss status were known; 2012 were exposed to smoke in-utero; 687 of them (34.1 %) ever had a fetal loss. Ever smokers with exposure in-utero ( Conclusions: In-utero smoke exposure is associated with increased odds of fetal loss when occurring in combination with active smoking of the participants, compounding the odds of fetal loss.

Indexed as

ALSPACCigarette smokeFetal lossIn-utero exposureTobacco

Identifiers

PMID40978675

DOI10.1016/j.pmedr.2025.103228

PMCPMC12444449

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.