ArticleFrontiers in medicine2025
Alterations in gut-kidney axis indicators and TMAO-related biomarkers in elderly patients with hypertensive nephropathy.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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13 authors.
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Abstract
Introduction: Growing evidence suggests that gut microbiota may influence renal function via the gut-kidney axis. This study assessed gut microbial composition, metabolic indicators, and inflammatory markers in elderly individuals with varying degrees of hypertensive kidney involvement. Methods: Seventy participants were stratified into three groups: healthy controls, hypertensive without renal impairment, and hypertensive with chronic kidney disease. Results: The chronic kidney disease group exhibited elevated serum urea and creatinine and reduced eGFR, along with increased levels of KIM-1, NGAL, IL-18, TNF-α, IL-6, NF-κB, and FMO3. Urinary TMAO was significantly decreased in both hypertensive groups, while serum TMAO remained unchanged. Although α- and β-diversity indices were comparable across groups, compositional shifts were noted, including higher relative abundance of Discussion: These findings suggest interrelated patterns involving gut microbial composition, toxin handling, and inflammatory status in elderly hypertensive individuals, supporting further investigation into microbiota-associated biomarkers within the framework of the gut-kidney axis.
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