ArticleCureus2025
Clinical Profile and Early Outcomes of Neonates With Hypernatremic Dehydration in a Neonatal Intensive Care Unit (NICU) Based in a Tertiary Care Hospital.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
introductionHypernatremic dehydration in neonates is a preventable but potentially fatal condition and often results from inadequate breastfeeding or inappropriate feeding methods. If not identified and managed promptly, it can result in serious complications such as acute kidney injury (AKI), intra-cranial hemorrhage, thrombosis, and increased risk of mortality.
methodsA prospective observational study was conducted over one year in the neonatal intensive care unit (NICU) of a tertiary hospital. Neonates with signs and symptoms of dehydration with serum sodium >145 mEq/L were included. Data was collected on demographic characteristics, clinical presentation, feeding practices, complications, and outcomes. Statistical analysis was done using chi-square test.
resultsOut of 60 neonates, 58.3% were preterm and 83.3% were low birth weight. Top feeding was observed in 66.6%. Common presentations were diarrhea (63%), refusal to feed (45%), and lethargy (30%). Complications included AKI (38.3%), intracranial bleed (8.3%) and thrombosis (8.3%). Mortality rate was 28.3%, significantly associated with AKI (p=0.0033), intracranial hemorrhage (p=0.0199), top feeding (p=0.034), and sodium >170 mEq/L (p=0.0051).
conclusionHypernatremic dehydration in neonates is associated with modifiable risk factors and has high complication rates. Proper feeding practices with emphasis on breastfeeding and early clinical recognition are critical in reducing mortality.
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