ArticleFrontiers in aging neuroscience2025
Muscle strength, EEG biomarkers, and working memory as interacting predictors of cognitive function in cognitively impaired older adults.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cognitive decline in older adults is a pressing public health concern, with emerging evidence suggesting that both muscle strength and neural function may influence cognitive outcomes. However, the integrative mechanisms linking these domains remain insufficiently understood. Objective: This study aimed to explore whether resting-state EEG characteristics and working memory mediate the relationship between muscle strength and global cognitive function in older adults with cognitive impairment. Methods: A cross-sectional study was conducted among 137 older adults (mean age = 72.65 ± 7.75) with cognitive impairment. Muscle strength was assessed using grip strength and 30 s chair stand tests. Resting-state EEG power across six frequency bands was recorded from 16 electrodes. Working memory was evaluated using a two-back task, and cognitive function was assessed via the MoCA. Mediation analyses were performed using the PROCESS macro (Model 4), controlling for age, sex, education, and BMI. Results: Grip strength showed significant direct effects on cognitive function ( Conclusion: This study highlights the distinct mediating roles of working memory and EEG features in the muscle strength-cognition relationship. Grip strength, as a potential biomarker, may reflect central nervous system integrity and serve as a target for cognitive health interventions in aging populations.
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