Evidence map›Paper›PMID 40979206›Full record

ArticleFrontiers in neurology2025

Sex differences in the clinical features of 2,841 patients with migraine: a

Marina Romozzi, Luigi Francesco Iannone, Marcello Silvestro, Giulia Paparella, Stefania Scannicchio, Stefania Battistini, Raffaele Ornello, Simona Sacco, Federico De Santis, Innocenzo Rainero and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Beyond a Diagnosis: A Qualitative Study Exploring Patient and Caregiver Expectations About Emergency Department Visits Amid Uncertainty.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Marina Romozzi *Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Luigi Francesco Iannone *Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Marcello SilvestroHeadache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giulia PaparellaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Stefania ScannicchioNeurology and Clinical Neurophysiology Unit, Headache Center, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Stefania BattistiniNeurology and Clinical Neurophysiology Unit, Headache Center, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Raffaele OrnelloDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Federico De SantisDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Innocenzo RaineroHeadache Center, Department of Neuroscience, University of Torino, Torino, Italy.
Andrea MarcinnòHeadache Center, Department of Neuroscience, University of Torino, Torino, Italy.
Gabriele SebastianelliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Chiara AbagnaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Paola SarchielliHeadache Center, Neurologic Clinic, University of Perugia, Perugia, Italy.
Ilenia CorbelliHeadache Center, Neurologic Clinic, University of Perugia, Perugia, Italy.
Gloria VaghiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Roberto De IccoDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Grazia SancesHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.
Cristina TassorelliDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Simona GuerzoniFondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Flavia Lo CastroFondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Antonio GranatoClinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Luca BartoleClinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Francesco De CesarisHeadache Center and Clinical Pharmacology, AOU Careggi, Florence, Italy.
Andrea BurgalassiHeadache Center and Clinical Pharmacology, AOU Careggi, Florence, Italy.
Giorgio Dalla VoltaHeadache Center of Neurological Unit of Istituto Clinico Città di Brescia, Brescia, Italy.
Matteo CortinovisHeadache Center of Neurological Unit of Istituto Clinico Città di Brescia, Brescia, Italy.
Martino GentileHeadache Center Neurological Clinica "L. Amaducci", AOUC Policlinic, Bari, Italy.
Paolo CalabresiDipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Maria Pia PrudenzanoHeadache Center Neurological Clinica "L. Amaducci", AOUC Policlinic, Bari, Italy.
Antonio RussoHeadache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marina de TommasoNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
RiCe study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Migraine occurs two to three times more frequently in women than in men, exhibiting different clinical characteristics in both sexes. The present study aims to investigate further and extend the findings of sex-specific migraine phenotypes in a large cohort of subjects with migraine enrolled in the "Italian Headache Registry" (RICe). Methods: This is a Results: We included 2,841 migraine subjects (80.0% women; mean age: 45.7 ± 14.3 years; mean MHDs 12.3 ± 9). Among them, 2,087 subjects had EM (73.5%), 754 (26.5%) had CM, and 273 (36.2%) had MOH. When considering individuals with EM and CM as a whole group, women reported higher pain intensity compared to men (NRS scale women [mean 7.6 ± 1.7] vs. men [7.0 ± 2.1], Conclusion: Women with EM or CM have higher pain intensity and more frequent concomitant migraine symptoms when compared to men. No sex-related differences were found in the frequency of MOH.

Indexed as

associated symptomsgenderheadache intensitymigrainesex

Identifiers

PMID40979206
PMCPMC12445143

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.