ArticleInternational journal of women's health2025
Association of WEE2 Gene Polymorphism with Fertilization Failure in Women Undergoing Intracytoplasmic Sperm Injection.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Novel biallelic PATL2 variants causing predominant germinal vesicle arrest and recurrent ART failure: expanded mutational spectrum and evidence-based reproductive counseling guidance.Journal of assisted reproduction and genetics · 2026Article
- Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression.Journal of developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Infertility and pregnancy loss are major concerns in reproductive medicine, often linked to genetic factors affecting oocyte maturation. The WEE2 gene, which encodes an oocyte-specific kinase critical for meiosis, plays a vital role in fertilization. Variants in WEE2 have been implicated in oocyte maturation arrest and total fertilisation failure (TFF), particularly in women undergoing assisted reproductive technologies. This study aimed to investigate the association between WEE2 gene polymorphism and fertilization failure in women undergoing intracytoplasmic sperm injection (ICSI). Materials and Methods: This prospective comparative study enrolled 137 infertile women undergoing ICSI procedures. Peripheral blood samples were collected from all participants for genetic analysis. Genotyping of the WEE2 gene variant rs1476640 was performed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay, which was specifically designed and optimised for this study. Results: WEE2 gene polymorphism (rs1476640) showed a significant association with fertilization outcomes (p < 0.0001). The T allele was protective, while the C allele increased the risk of fertilization failure (OR = 9.06; 95% CI: 3.27-25.14). Significant differences were also observed in infertility duration, oocyte count, and endometrial thickness between pregnant and non-pregnant women (p < 0.05), but not in age or BMI. Conclusion: The WEE2 rs1476640 polymorphism is significantly associated with fertilization failure in ICSI-treated women. Screening for this variant may help identify patients at risk and support personalised infertility treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.