SynthesisFrontiers in bioengineering and biotechnology2025
Hyaluronic acid as a biomaterial for dental pulp regeneration: a systematic review of preclinical studies.
Synthesis in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Hydrogel-based strategies for dentin-pulp complex regeneration: a comprehensive review.Cell and tissue banking · 2026Review
- Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review.Journal of clinical medicine · 2026Review
- Effects ofCurrent issues in molecular biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: With the current advancements in regenerative medicine, it has become necessary to refine the current regenerative endodontic procedure (REP). Scaffold improvement, including the use of hyaluronic acid as a natural biomaterial, has been the subject of many studies. This systematic review aims to explore the effects of hyaluronic acid (HA) on dental pulp regeneration. Methods: A comprehensive search on Hinari, PubMed, Springer, and ScienceDirect databases in July 2024 was carried out. All Results: A total of 23 articles were included, comprising 17 Discussion: The variability in the study design has made it difficult to assert the results; however, most studies agree that HA has promising potential in REP. Systematic Review Registration: [https://osf.io/t45ec/].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.