ArticleJournal of biomedical optics2025
Asynchronous optical coherence elastography and directional phase gradient analysis.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Super-resolution wave-dispersion analysis in optical coherence elastography using multiple signal classification (MUSIC).Biomedical optics express · 2026Article
- Multi-frequency asynchronous optical coherence elastography by direct demodulation.Biomedical optics express · 2026Article
- Editorial: Advances in Optical Elastography.Journal of biomedical optics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Significance: The stiffness and compliance of biological tissues are key properties that often change in the presence of pathology, yet current shear wave elastography approaches using optical coherence tomography (OCT) face limitations due to slow image acquisition, sensitivity to motion artifacts, and reliance on advanced hardware, hindering clinical translation. Aim: The aim is to develop and validate a practical, high-speed method for three-dimensional shear wave imaging compatible with standard OCT systems and wave propagation variability. Approach: We introduce a technique for the rapid, asynchronous acquisition of three-dimensional shear wave fields. Our technique operates at conventional acquisition rates and utilizes pairs of B-scans, similar to angiography scanning protocols. This approach significantly reduces motion sensitivity and enhances acquisition speed, even with much denser lateral sampling. In addition, we present a technique for estimating the shear wave number, termed directional phase gradient analysis. This method computes the phase gradient of the autocorrelation of the directionally-filtered, complex-valued shear wave and is robust across unidirectional, partially diffuse, and fully diffuse shear wave conditions. Results: We validated the accuracy of our techniques through direct comparison with phase-locked, synchronous-mode imaging in benchtop experiments using tissue-mimicking phantoms. Furthermore, we demonstrated their robustness to variations in wave orientation, excitation amplitude, and diffusivity, as confirmed by repeated measurements on the same sample under diverse conditions. Conclusions: Together, these methods may offer a more practical approach for shear wave imaging without requiring modifications to existing clinical phase-stable OCT systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.