Evidence map›Paper›PMID 40979903›Full record

ReviewBurns & trauma2025

From injury to integrity: tissue engineering solutions in combined bone repair and regeneration and muscle repair.

Yesheng Jin, Yixue Huang, Jia Wang, Xinfeng Zhou, Jianan Chen, Wenge Ding, Zhihao Jia, Yong Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yesheng JinDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, No. 899 Pinghai Road, Suzhou 215000, Jiangsu, China.
Yixue HuangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, No. 899 Pinghai Road, Suzhou 215000, Jiangsu, China.
Jia WangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, No. 899 Pinghai Road, Suzhou 215000, Jiangsu, China.
Xinfeng ZhouDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, No. 899 Pinghai Road, Suzhou 215000, Jiangsu, China.
Jianan ChenDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, No. 899 Pinghai Road, Suzhou 215000, Jiangsu, China.
Wenge DingDepartment of Traumatic Orthopaedics, Third Affiliated Hospital of Soochow University, Soochow University, No. 185 Juqian Road, Changzhou 213003, Jiangsu, China.
Zhihao JiaCambridge-Suda Genomic Resource Center, Suzhou Medical College, Soochow University, No. 199 Ren ai Road, Suzhou 215000, Jiangsu, China.
Yong XuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, No. 899 Pinghai Road, Suzhou 215000, Jiangsu, China.ORCID https://orcid.org/0000-0002-9746-6004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The musculoskeletal system is essential for human movement. However, the increasing incidence of complex musculoskeletal injuries, which involve substantial loss of soft (muscle, skin) and hard (bone) tissues poses significant clinical challenges. Autogenous and allogeneic bone grafts are the most commonly adopted surgical methods for severe bone defects. However, severe postoperative complications, such as immune rejection and donor site necrosis, can lead to poor prognosis. Additionally, the scarcity of bone graft sources limits their application. Moreover, soft tissue injuries are often inadequately addressed in orthopedic procedures, leading to impaired muscle function and highlighting the urgent need for new strategies in integrated musculoskeletal repair. This review explores tissue engineering solutions by examining the interplay between muscle and bone physiology, elucidating their regenerative mechanisms, and evaluating innovations such as hydrogels, electrospun fibers, and conductive scaffolds for tissue repair. We advocate for integrated strategies that target the simultaneous restoration of soft and hard tissues to improve clinical outcomes.

Indexed as

Conductive materialElectrospun fiber materialHydrogel materialMusculoskeletal repairOpen bone injury

Identifiers

PMID40979903
PMCPMC12449194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.