ArticleFrontiers in psychiatry2025
High-density lipoprotein is inversely associated with psychiatric symptoms across diagnoses in patients with general psychiatric disorders.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bidirectional genetic overlap between psychiatric disorders and high-density lipoprotein cholesterol levels.Lipids in health and disease · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lipids are essential in cell structure and function in all parts of the body including the brain. Thus, lipids are of obvious relevance in psychiatric disorders. While the role of lipids in pathophysiological processes in cardiovascular disorders are widely known, the role of lipids in function and pathophysiology of mental processes are far less established. This study aimed to explore serum lipid levels and their association in a clinical cohort with general psychiatric symptoms. Methods: A transdiagnostic sample of 132 patients was recruited from a general open psychiatric ward to this cross-sectional naturalistic study. Psychiatric symptoms were assessed using the Symptom Checklist-90-Revised (SCL-90-R). Serum levels of triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were measured, and multiple linear regression analysis were performed to investigate associations with symptom clusters from SCL-90-R. Results: After correcting for the most common confounding factors, HDL was negatively associated with intensity of phobic anxiety ( Conclusion: HDL was significant inversely associated with several general psychiatric symptoms. This result indicates a role for lipids in the pathophysiology of psychiatric disorders and suggests a mechanism for the increased cardiovascular risk across psychiatric diagnoses.
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