ReviewFrontiers in cardiovascular medicine2025
A systematic review of the connection between serum uric acid levels and the risk of cardiovascular disease.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Serum Uric Acid and Mortality Risk in Chronic Kidney Disease: A Dose-Response Analysis.Journal of clinical medicine · 2026Article
- Serum Uric Acid Is Associated with CT-Derived Aortic Valve Calcification in Low-Flow, Low-Gradient Aortic Stenosis with Reduced Ejection Fraction.Journal of cardiovascular development and disease · 2026Article
- [Hyperuricaemia as a cardiovascular risk factor].Atencion primaria · 2026Article
- Higher serum uric acid levels are associated with an increased risk of carotid atherosclerosis in 67,256 adults.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum uric acid (SUA) has emerged as a significant biomarker for cardiovascular disease (CVD) risk assessment, garnering increasing attention in recent years. As CVD remains a leading cause of global mortality, identifying effective biomarkers for risk stratification is of paramount importance. Current evidence indicates a strong association between elevated SUA levels and increased CVD risk. However, the precise mechanisms and confounding factors underlying this relationship remain unclear. This review examines the link between SUA and CVD, exploring potential biological pathways-including metabolic syndrome, inflammatory responses, and oxidative stress-that may mediate this association. By synthesizing existing literature, this article aims to provide insights for future research and clinical applications, ultimately enhancing the understanding of SUA's utility in CVD risk evaluation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.