ArticleArthroscopy, sports medicine, and rehabilitation2025
Angiotensinogen II Receptor Blockers May Decrease Risk of Adhesive Capsulitis After Rotator Cuff Repair.
Article in Arthroscopy, sports medicine, and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Perioperative antihypertensive medication use is associated with no antifibrotic benefit but higher complications and revision rates following shoulder arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To determine the effect of commonly prescribed antifibrotic medications on the odds of developing adhesive capsulitis (AC) following arthroscopic rotator cuff repair. Methods: The Mariner data set of the PearlDiver database from 2010 to 2022 was used to identify patients aged 40 to 65 years who underwent rotator cuff repair (identified by Current Procedural Terminology codes) with an ipsilateral rotator cuff tear (identified by International Classification of Diseases, 10th Revision codes). Patients were required to have filled a prescription for only one of the following medications before and within 3 months of surgery: angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors, cyclooxygenase 2 inhibitors, and statins. Patients who developed ipsilateral AC within 6 months after surgery were identified using International Classification of Diseases codes. Additionally, all patients who underwent a manipulation under anesthesia (MUA) and/or arthroscopic lysis of adhesions (LOA) within 6 months of diagnosis of AC were identified using Current Procedural Terminology codes. Results: A total of 183,563 patients met study inclusion criteria and were stratified based on the development of postoperative AC. The baseline characteristics (age, sex, smoking status, and diabetes and obesity prevalence) between the 2 groups were statistically different, except for the Charlson Comorbidity Index. In total, 4.62% (8,485/183,563) developed postoperative AC, and 8.5% (717/8,485) and 5.2% (438/8,485) of patients who developed AC underwent subsequent MUA and LOA, respectively. Patients on an ARB had an odds ratio of 0.87 ( Conclusions: Patients on an ARB had lower odds of being diagnosed with AC within 6 months of surgery. Once diagnosed with AC, there was no difference in odds of undergoing MUA or LOA among any of the medication groups. Level of Evidence: Level III, retrospective cohort study.
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Registered trials
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