Evidence map›Paper›PMID 40980294›Full record

ArticleWorld journal of diabetes2025

Albuminuria is independently associated with preclinical left ventricular systolic dysfunction: The TESEO study.

Federica Barutta, Alessandro Andreis, Matteo Bellettini, Guglielmo Beccuti, Arianna Ferro, Martina Bollati, Stefania Bellini, Giulia Gioiello, Giulio Mengozzi, Gaetano M De Ferrari and 3 more

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Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Federica BaruttaDepartment of Medical Sciences, University of Turin, Turin 10126, Italy. federica.barutta@unito.it.
Alessandro AndreisDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Matteo BellettiniDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Guglielmo BeccutiDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Arianna FerroDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Martina BollatiDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Stefania BelliniDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Giulia GioielloDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Giulio MengozziDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Gaetano M De FerrariDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Gianluca AlunniDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Fabio BroglioDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.
Gabriella GrudenDepartment of Medical Sciences, University of Turin, Turin 10126, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobal longitudinal strain (GLS) of the left ventricular is a highly sensitive and reliable marker of systolic function and GLS outperforms ejection fraction (EF) in detecting preclinical left ventricular systolic dysfunction (LVSD). In patients with type 2 diabetes (DM2) albuminuria is a predictor of symptomatic heart failure, but data on the relationship between GLS and albuminuria are conflicting.

aimTo explore the relationship between GLS and albuminuria in a contemporary cohort of DM2 patients.

methodsThe study was performed on DM2 patients consecutively enrolled in the TESEO study. Patients with symptoms/signs of heart failure, EF < 50%, coronary artery, other cardiac diseases, or non-adequate acoustic window for GLS assessment were excluded. We collected clinical data, screened for complications, and measured GLS by speckle-tracking echocardiography. Univariate and multiple linear regression analyses were performed to identify independent explanatory variables associated with GLS. Logistic regression analysis was used to assess whether albuminuria was independently associated with GLS-diagnosed (GLS > -18%) LVSD.

resultsPatients (

conclusionAlbuminuria was independently associated with subclinical LVSD in our contemporary cohort of DM2 patients.

Indexed as

AlbuminuriaGlobal longitudinal strainHeart failureLeft ventricular systolic dysfunctionType 2 diabetes

Identifiers

PMID40980294
PMCPMC12444262

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.