Trial reportDrug design, development and therapy2025
The Optimal Doses of Dexmedetomidine Combined with Propofol in Patients in Hysteroscopic Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of Perioperative Dexmedetomidine Exposure with Flap Failure After Head and Neck Surgery Flap Reconstruction: A Retrospective Study.Drug design, development and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dexmedetomidine has been reported to be utilized in conjunction with propofol during hysteroscopic surgery. However, both dexmedetomidine and propofol have benefits and side-effects, and the optimal doses of dexmedetomidine when utilized in combination with propofol during hysteroscopic surgery remain unestablished. Methods: One hundred and fifty patients undergoing hysteroscopic surgery at the affiliated hospital of North Sichuan Medical College were randomly divided into five groups and administered dexmedetomidine at a dose of 0.4 µg/kg, 0.6 µg/kg, 0.8 µg/kg, or 1.0 µg/kg, or saline, prior to anesthesia induction. Before the surgery, propofol was administered via target-controlled infusion using a pump with the Marsh model. The EC Results: The EC50 of propofol was significantly lower in the Dex 0.6, Dex 0.8, and Dex 1.0 groups compared to the S group ( Conclusion: Dexmedetomidine 0.8 µg/kg offers an optimal balance between propofol-sparing effects, sedation quality, and manageable side effects for hysteroscopic surgery. Trial Registration: Date of registration: 24/05/2020, registration number: ChiCTR2000033220.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.