Evidence map›Paper›PMID 40980435›Full record

ArticleMolecular therapy. Methods & clinical development2025

Durable tissue-specific transgene expression in newborn mice following intraperitoneal delivery of non-cytotoxic HSV vectors.

Yoshitaka Miyagawa, Motoyo Maruyama, Atsushi Sakai, Yuriko Sato, Masumi Shimizu, Seiji Kuroda, Hiromi Hayashita-Kinoh, Motoko Yamamoto, Ryotaro Hashizume, Hidenori Suzuki and 3 more

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In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yoshitaka MiyagawaDepartment of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan.
Motoyo MaruyamaDepartment of Pharmacology, Nippon Medical School, Tokyo, Japan.
Atsushi SakaiDepartment of Pharmacology, Nippon Medical School, Tokyo, Japan.
Yuriko SatoDepartment of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan.
Masumi ShimizuDepartment of Microbiology and Immunology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-0031, Japan.
Seiji KurodaDepartment of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan.
Hiromi Hayashita-KinohDivision of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Motoko YamamotoDepartment of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan.
Ryotaro HashizumeDepartment of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Hidenori SuzukiDepartment of Pharmacology, Nippon Medical School, Tokyo, Japan.
Justus B CohenDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA USA.
Joseph C GloriosoDepartment of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA USA.
Takashi OkadaDivision of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report describes the distribution and transgene expression of two non-cytotoxic, replication-defective (rd) herpes simplex virus (HSV) vectors, JΔNI7 and JΔNI8, following intraperitoneal delivery to newborn mice. The two vectors are functionally defective for all immediate-early genes, and JΔNI8 is further deleted for the UL41 endonuclease (

Indexed as

biodistributiongene therapyherpes-simplex-virus-based vectorin vivo imagingnon-cytotoxic HSV vectortissue-specific expressionUL41vector toxicity

Identifiers

PMID40980435
PMCPMC12446203

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.