Evidence mapPaperPMID 40980454Full record

ArticleIEEE open journal of ultrasonics, ferroelectrics, and frequency control2025

Photo-Mediated Ultrasound Therapy (PUT) for the Treatment of Deep Cutaneous Vasculature.

Mingyang Wang, Jeffrey S Orringer, Yannis M Paulus, Xinmai Yang, Xueding Wang

Abstract read
In one paragraph

Article in IEEE open journal of ultrasonics, ferroelectrics, and frequency control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingyang WangUniversity of Michigan, Ann Arbor, MI 48109 USA.ORCID 0000-0002-4076-1643
Jeffrey S OrringerUniversity of Michigan, Ann Arbor, MI 48109 USA.
Yannis M PaulusJohns Hopkins University, Baltimore, MD 21218 USA.ORCID 0000-0002-0615-628X
Xinmai YangThe University of Kansas, Lawrence, KS 66045 USA.ORCID 0000-0001-8120-6593
Xueding WangUniversity of Michigan, Ann Arbor, MI 48109 USA.ORCID 0000-0002-2974-6258

Funding

Precisely removing microvessels by photo-mediated ultrasound therapyR01EY029489 · NEI · UNIVERSITY OF KANSAS LAWRENCE · PI YANG, XINMAI · 2018 to 2021
$1.8M
Real-time In Vivo Visualization of the Molecular Processes in Choroidal NeovascularizationK08EY027458 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAULUS, YANNIS MANTAS · 2018 to 2021
$898k
Photo-mediated ultrasound therapy for treatment of cutaneous vascular malformationsR41EB030875 · NIBIB · PHOTOSONOX LLC · PI WANG, XUEDING, YANG, XINMAI · 2020 to 2020
$325k
Novel Nanosecond Laser and Ultrasound to Selectively Treat Eye Blood VesselsR41EY031219 · NEI · PHOTOSONOX LLC · PI PAULUS, YANNIS MANTAS · 2020 to 2020
$225k
NEI NIH HHS K08 EY027458NEI NIH HHS R01 EY029489NEI NIH HHS R41 EY031219NIBIB NIH HHS R41 EB030875
6 · The paper itself

Abstract

Traditionally, pulsed dye laser (PDL) therapy has been used to treat cutaneous blood vessels in patients with port-wine stain (PWS) birthmarks. PDL therapy, however, has limited treatment depth, and frequently results in suboptimal therapeutic outcomes when used to treat deep cutaneous blood vessels. We have developed photo-mediated ultrasound therapy (PUT), a hybrid cavitation-based anti-vascular technology combining nanosecond light pulses with ultrasound bursts and demonstrated its great potential in treating deep cutaneous vessels. This study explored the feasibility of PUT as an alternative to traditional PDL therapy for deep cutaneous vascular treatment in a clinically relevant chicken wattle model. PUT was employed to induce cavitation in blood vessels by using different light fluence and ultrasound pressure combinations. Theoretical modeling and

Indexed as

Deep cutaneous vasculaturephotoacousticphotomechanical effectphoto-mediated ultrasound therapyport-wine stains

Identifiers

PMID40980454
PMCPMC12448061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.