Evidence map›Paper›PMID 40980724›Full record

ReviewEuropean heart journal open2025

Association between non-invasive auricular stimulation and blood pressure lowering: a systematic review and meta-analysis.

Michiaki Nagai, Karl-Philipp Rommel, Yukiko Nakano, Phillip J Tully, Isabel J Sible, Sunny Po, Tarun W Dasari

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michiaki NagaiCardiovascular Section, Department of Medicine, University of Oklahoma, Health Science Center, Andrews Academic Tower, Suite 5400, Oklahoma City, OK 73104, USA.ORCID https://orcid.org/0000-0002-3838-1369
Karl-Philipp RommelDepartment of Cardiology, University Medical Center Mainz and German Center for Cardiovascular Research, Langenbeckstrasse 1, 55131 Mainz, Germany.
Yukiko NakanoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 7348551, Japan.
Phillip J TullyFaculty of Medicine and Health, School of Psychology, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia.
Isabel J SibleDepartment of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA 94158, USA.
Sunny PoCardiovascular Section, Department of Medicine, University of Oklahoma, Health Science Center, Andrews Academic Tower, Suite 5400, Oklahoma City, OK 73104, USA.ORCID https://orcid.org/0000-0002-5283-6737
Tarun W DasariCardiovascular Section, Department of Medicine, University of Oklahoma, Health Science Center, Andrews Academic Tower, Suite 5400, Oklahoma City, OK 73104, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier clinical trials have investigated the efficacy of auricular stimulation for hypertension, but the overall evidence regarding the effect of non-invasive auricular stimulation on blood pressure (BP) reduction remains unclear. This systematic review summarizes the effects of non-invasive auricular stimulation on cardiovascular haemodynamics. We searched for studies published in English through PubMed, ICHUSHI, and Cochrane Central Library databases and reviewed randomized controlled trials involving adults. Data collection and analysis were performed on the relationships of non-invasive auricular electrical stimulation and acupressure with changes in haemodynamics. A meta-analysis was conducted on the effects of non-invasive auricular stimulation on systolic BP (SBP), diastolic BP (DBP), and heart rate (HR). In the primary analysis, effect sizes were extracted from 18 studies for a total analytic sample of

Indexed as

Auricular stimulationAutonomic nervousBlood pressureHeart rateVagus nervous system

Identifiers

PMID40980724
PMCPMC12445708

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.