Evidence map›Paper›PMID 40980868›Full record

ArticleNeurogastroenterology and motility2026

Relationship Between Intragastric Meal Distribution, Gastric Emptying, and Gastric Neuromuscular Dysfunction in Chronic Gastroduodenal Disorders.

Chris Varghese, Armen A Gharibans, Daphne Foong, Gabriel Schamberg, Stefan Calder, Vincent Ho, Reena Anand, Christopher N Andrews, Alan H Maurer, Thomas Abell and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Chris VargheseDepartment of Surgery, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0001-7369-8639
Armen A GharibansDepartment of Surgery, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-9139-4740
Daphne FoongDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Gabriel SchambergDepartment of Surgery, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-4188-9614
Stefan CalderDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Vincent HoWestern Sydney University, Sydney, New South Wales, Australia.
Reena AnandDepartment of Medicine, Temple University Hospital, Philadelphia, Pennsylvania, USA.
Christopher N AndrewsAlimetry Ltd, Auckland, New Zealand.
Alan H MaurerDepartment of Medicine, Temple University Hospital, Philadelphia, Pennsylvania, USA.
Thomas AbellDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-3175-5161
Henry P ParkmanDepartment of Medicine, Temple University Hospital, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-4904-4891
Greg O'GradyDepartment of Surgery, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-5998-1080

Funding

Health Research Council of New ZealandNew Zealand Society of Gastroenterology Janssen Research FellowshipNIH HHS
6 · The paper itself

Abstract

backgroundChronic gastroduodenal symptoms arise from heterogeneous gastric motor dysfunctions. This study applied multimodal physiological testing using gastric emptying scintigraphy (GES) with intragastric meal distribution (IMD) and Gastric Alimetry body surface gastric mapping (BSGM) to define motility and symptom associations.

methodsPatients with chronic gastroduodenal symptoms underwent simultaneous supine GES and BSGM with a 30 m baseline, 99mTC-labeled egg meal, and 4 h postprandial recording. IMD (ratio of counts in the proximal half of the stomach to the total gastric counts) was calculated immediately after the meal (IMD0), with < 0.568 defining abnormal IMD. BSGM phenotyping followed a consensus approach, based on normative spectral reference intervals.

resultsAmong 67 patients (84% female, median age 40 years, median BMI 24 kg/m

conclusionProximal retention of food as assessed by IMD correlated with delayed emptying, and in the presence of neuromuscular spectral abnormalities (abnormal frequencies or rhythms), delayed motility responses on BSGM. Patients with multiple motor abnormalities experience worse dyspeptic symptoms.

Indexed as

Gastric EmptyingMealsStomachAdultChronic DiseaseFemaleGastroparesisHumansMaleMiddle AgedPostprandial PeriodRadionuclide Imagingbody surface gastric mappingdyspepsiagastroparesisintragastric meal distributionscintigraphy

Identifiers

PMID40980868
PMCPMC12814998

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.