Evidence map›Paper›PMID 40980879›Full record

ArticlemBio2025

Insight on the roles of stringent response, stringent-like response, and general stress response in hyperosmotic shock tolerance in

Keilen Kelly, Rajeev Misra

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Keilen KellySchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.ORCID 0009-0004-0608-4038
Rajeev MisraSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0001-8007-420X

Funding

Detailed mapping of drug binding and translocation sites in the AcrB pump proteinR21AI117150 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MISRA, RAJEEV · 2016 to 2017
$408k
NIAID NIH HHS R21 AI117150
6 · The paper itself

Abstract

Bacteria frequently encounter osmotic stress in a variety of natural environments, and the primary protective systems they use to adapt to such stresses have been well-characterized. The work examining these mechanisms has largely focused on their role in adapting to moderate shock or continuous osmotic stress. However, survival of rapid, severe osmotic stress remains poorly understood. Here, we demonstrate that a pleiotropic mutation,

Indexed as

Escherichia coliOsmotic PressureStress, PhysiologicalAdaptation, PhysiologicalBacterial ProteinsDNA-Directed RNA PolymerasesEscherichia coli ProteinsGene Expression Regulation, BacterialMutationSigma FactorBacterial ProteinsDNA-Directed RNA PolymerasesEscherichia coli ProteinsrpoB protein, E coliSigma Factorsigma factor KatF protein, Bacteriageneral stress responseosmotic stressRelA/SpoTrpoBrpoSstringent response

Identifiers

PMID40980879
PMCPMC12607593

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.