Evidence map›Paper›PMID 40980890›Full record

ArticlemBio2025

IL-4 downregulates gap junction protein connexin 26 to promote HIV-1 infection in macrophages.

Shumei Wang, Jingjing Zhang, Yuan Liu, Li Zhao, Yimin Zhang, Guoxin Liang, Hong Shang

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shumei Wang *State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Health Commission Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.ORCID 0009-0008-6082-135X
Jingjing Zhang *State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Health Commission Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Yuan LiuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Health Commission Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Li ZhaoState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Health Commission Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Yimin ZhangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-5877-6675
Guoxin LiangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Health Commission Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.ORCID 0000-0003-1789-9094
Hong ShangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Health Commission Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.ORCID 0000-0001-5333-8943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages and dendritic cells (DCs) are important targets for HIV-1 replication IMPORTANCE: HIV-1 primarily targets two groups of cells

Indexed as

Connexin 26HIV-1HIV InfectionsInterleukin-4MacrophagesCD4-Positive T-LymphocytesDendritic CellsDown-RegulationHumansVirus ReplicationConnexin 26GJB2 protein, humanIL4 protein, humanInterleukin-4GJB2HIV-1IL-4

Identifiers

PMID40980890
PMCPMC12607889

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.