Evidence map›Paper›PMID 40980929›Full record

ArticleInfection and immunity2025

Myeloid cell-specific type I interferon signaling mediates age-dependent inflammation and protection in

Amit Kumar, Alicia Bukowski, Nicholas H Carbonetti

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amit KumarDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0009-0002-6111-635X
Alicia BukowskiDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Nicholas H CarbonettiDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4532-7192

Funding

Age-dependent role of type I interferon in Bordetella pertussis pathogenesisR01AI141372 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARBONETTI, NICHOLAS H · 2018 to 2022
$1.9M
Age-dependent role of interferon lambda in protection against pertussis lethality in infantsR21AI168603 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARBONETTI, NICHOLAS H · 2023 to 2024
$425k
American Association of Immunologists AAINational Institute of Allergy and Infectious Diseases AI141372National Institute of Allergy and Infectious Diseases AI168603NIAID NIH HHS R01 AI141372NIAID NIH HHS R21 AI168603
6 · The paper itself

Abstract

Type I interferons (IFNs) play complex roles during bacterial infections. We previously found that type I IFNs were induced in

Indexed as

Bordetella pertussisInflammationInterferon Type IMyeloid CellsSignal TransductionWhooping CoughAge FactorsAnimalsMacrophagesMiceMice, Inbred C57BLMice, KnockoutPertussis ToxinReceptor, Interferon alpha-betaIfnar1 protein, mouseInterferon Type IPertussis ToxinReceptor, Interferon alpha-betaBordetella pertussisinfant infectioninnate immunityinterferon lambdapertussis toxinrespiratory infectiontype I interferon

Identifiers

PMID40980929
PMCPMC12519780

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.