Evidence map›Paper›PMID 40981208›Full record

ArticleClocks & sleep2025

The Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis.

Anhui Wang, Jeroen Vreijling, Aldo Jongejan, Valentina S Rumanova, Ruth I Versteeg, Andries Kalsbeek, Mireille J Serlie, Susanne E la Fleur, Peter H Bisschop, Frank Baas and 1 more

Abstract read
In one paragraph

Article in Clocks & sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Light therapy in medicine: where do we stand?Annals of translational medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anhui WangDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0009-0009-0577-6610
Jeroen VreijlingDepartment of Clinical Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-4542-3264
Aldo JongejanLaboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam University Medical Center (UMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-8948-2549
Valentina S RumanovaDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-9920-7009
Ruth I VersteegDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Andries KalsbeekDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-9606-8453
Mireille J SerlieDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Susanne E la FleurLaboratory of Endocrinology, Department of Laboratory Medicine, Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Peter H BisschopDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Frank BaasDepartment of Clinical Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-3912-5428
Dirk J StenversDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam University Medical Center (UMC), University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-9519-5140

Funding

China Scholarship Council 202106820018STW OnTime 12189
6 · The paper itself

Abstract

The circadian rhythm of the central brain clock in the suprachiasmatic nucleus (SCN) is synchronized by light. White adipose tissue (WAT) is one of the metabolic endocrine organs containing a molecular clock, and it is synchronized by the SCN. Excess WAT is a risk factor for health issues including type 2 diabetes mellitus (DM2). We hypothesized that bright-light exposure would affect the human WAT transcriptome. Therefore, we analyzed WAT biopsies from two previously performed randomized cross-over trials (trial 1:

Indexed as

bright lightgene set enrichmentobesityRNA sequencingtranscriptomewhite adipose tissue (WAT)

Identifiers

PMID40981208
PMCPMC12452623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.