Evidence map›Paper›PMID 40981413›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Apolipoprotein C3 Promotes Angiogenesis in an Inflammatory Mouse Model of Peripheral Artery Disease.

Jordyn M Thomas, Panashe Bamhare, Jocelyne Mulangala, Christina A Bursill, Stephen J Nicholls, Belinda A Di Bartolo, Kristen J Bubb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Apolipoprotein C3 Promotes Angiogenesis in an Inflammatory Mouse Model of Peripheral Artery Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jordyn M ThomasDepartment of Physiology, Faculty of Medicine, Nursing and Health Sciences, Biomedicine Discovery Institute, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0001-7544-4077
Panashe BamhareVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Jocelyne MulangalaVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Christina A BursillVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0002-0682-8760
Stephen J NichollsVictorian Heart Institute, Monash University, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0002-9668-4368
Belinda A Di BartoloVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-8420-0461
Kristen J BubbDepartment of Physiology, Faculty of Medicine, Nursing and Health Sciences, Biomedicine Discovery Institute, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0002-3846-1414

Funding

MU | Monash Biomedicine Discovery Institute, Monash University (BDI)
6 · The paper itself

Abstract

Apolipoprotein C3 (ApoC3) regulates triglyceride metabolism and is associated with accelerated atherogenesis and adverse cardiovascular outcomes. However, its role in peripheral artery disease (PAD) remains unclear. We investigated whether Apoc3 deficiency impacts key features of PAD. Vascularization was assessed using an inflammatory periarterial cuff model (21 days) and a hind limb ischemia model (14 days) in male and female Apoc3

Indexed as

Apolipoprotein C-IIIInflammationNeovascularization, PathologicNeovascularization, PhysiologicPeripheral Arterial DiseaseAngiogenesisAnimalsDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsIschemiaMaleMiceMice, Inbred C57BLMice, KnockoutApolipoprotein C-IIIapolipoprotein C‐IIIendothelial cellshypoxia‐inducible factor 1 alpha subunit (HIF‐1α)inflammationmacrophagespathological angiogenesisperipheral arterial diseasephysiologic neovascularizationtriglyceridesvascular endothelial growth factor A (VEGFA)

Identifiers

PMID40981413
PMCPMC12452218

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.