ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2026
Rural-urban differences in osteoporosis and sarcopenia prevalence among Gambian older adults: a pilot study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Leveraging interpretable machine learning to identify sarcopenia in middle-aged and older adults with intrinsic capacity decline: an analysis of CHARLS data under AWGS 2025.BMC medical informatics and decision making · 2026Article
- Article
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9 authors.
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Abstract
Rural-urban BMD differences are well described in high-income countries, typically with higher BMD in rural areas. However, despite rapid urbanization and longevity across Africa, such data remain scarce. This study compares bone and muscle health in older adults living in rural and urban Gambia. Participants aged ≥55 yr from rural (n = 209) and urban (n = 101) communities were measured with DXA (TH, FN, and LS) and peripheral QCT (pQCT; diaphyseal and epiphyseal radius and tibia). Outcomes were DXA areal BMD (aBMD), BMC, bone area (BA); pQCT total volumetric BMD (vBMD), trabecular vBMD, bone strength indices (BSIc), cross-sectional area (CSA), BMC, and cortical vBMD. Osteoporosis (NHANES III, T-score < -2.5) and sarcopenia (revised European Working Group on Sarcopenia in Older People [EWGSOP2] appendicular lean mass [ALM] and handgrip strength [HGS]) prevalence were computed. Linear regression was used to describe rural-urban differences in DXA and pQCT outcomes (1) age-adjusted and (2) adjusted for age and fat mass index (FMI). Osteoporosis at either the FN or TH was more prevalent in urban men (20% vs rural 10%) and rural women (45% vs urban 31%). LS T-scores < -2.5 were more common in rural participants (men: 27% vs 14%; women: 61% vs 35%). Sarcopenia was also higher in rural participants (men: 30% vs. 18%; women: 18% vs 15%). Adjusted for age and FMI urban Gambians had lower BMC but greater BA at the FN and TH, while aBMD differed little. Urban men had lower adjusted tibial cortical vBMD but greater tibial diaphyseal and radial epiphyseal CSA. After adjustment, urban women had greater radial CSA and estimated strength. Our findings highlight that osteoporosis and sarcopenia are highly prevalent in older Gambian adults, with differences in rural-urban prevalence influenced by sex. Given ongoing nutrition transition and urbanization across Africa, larger population-based studies are urgently required to better inform targeted prevention strategies and interventions.
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