ArticleThe Journal of general virology2025
Temporal dynamics of koala retrovirus plasma RNA load in relation to faecal glucocorticoid metabolites and Chlamydia infection.
Article in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Koala retrovirus (KoRV) is endemic throughout northern koala populations that are currently in steep decline. We have previously found a strong association between KoRV plasma RNA loads and the risk of secondary diseases, including chlamydiosis. However, it is unclear whether (1) KoRV loads are elevated in sick koalas due to the expansion of leucocyte populations; and/or (2) KoRV induces immunosuppression, increasing susceptibility to disease; and/or (3) KoRV and secondary diseases are related through a third variable such as the physiological stress response. Here, we assess the temporal dynamics of KoRV load over a year and, in relation to chlamydia, to explore the causal direction of their relationship. We also investigated co-variation in faecal glucocorticoid metabolites (FGMs: cortisol and corticosterone) with KoRV load and chlamydia. We found that KoRV load was stable within individuals over time. KoRV load did not increase in wild koalas when they began shedding
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