Observational studyPloS one2025
Three-year outcomes of cystotomy for cystoid macular edema secondary to retinal vein occlusion.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective observational study evaluated the three-year clinical outcomes of cystotomy for managing refractory cystoid macular edema (CME) secondary to retinal vein occlusion (RVO). A total of 23 eyes from 23 patients (10 males, 13 females) with CME secondary to RVO (RVO-ME) who underwent cystotomy at Kobe University Hospital between September 2014 and July 2021 were reviewed, with a minimum follow-up of 3 years. Clinical parameters such as age, sex, best-corrected visual acuity (BCVA), central retinal thickness (CRT), number of treatments (anti-vascular endothelial growth factor injections, sub-Tenon triamcinolone acetonide injections, microaneurysm photocoagulation, and pars plana vitrectomy), number of outpatient visits, presence of fibrinogen clot removal, and recurrence were retrospectively analyzed. The mean age was 72.3 ± 10.3 years. Mean BCVA improved from 0.33 ± 0.24 logarithm of the minimum angle of resolution preoperatively to 0.21 ± 0.22 at 3 years (p < 0.001). CRT significantly decreased from 504.7 ± 118.2 μm to 295.2 ± 87.4 μm (p < 0.001). The average annual number of total treatments decreased from 3.7 ± 1.8 to 1.1 ± 3.1 (p < 0.001), and outpatient visits decreased from 11.8 ± 4.0 to 4.4 ± 3.2 (p < 0.001). Fibrinogen clot removal was performed in nine eyes. Recurrence was observed in eight eyes. Cystotomy appeared to be a promising surgical option for managing refractory RVO-ME.
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