Evidence map›Paper›PMID 40983473›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2025

Scar wars: the viral menace.

Sara Kass-Gergi, Nicolas P Holcomb, Michael M Maiden, Laurence C Eisenlohr, Andrew E Vaughan

Abstract readReview
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sara Kass-GergiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0003-3437-2147
Nicolas P HolcombDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0009-0004-3517-4745
Michael M MaidenDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Laurence C EisenlohrDepartment of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Andrew E VaughanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0001-5740-643X

Funding

Coordinated regeneration of lung epithelial and endothelial compartmentsR01HL164350 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2022 to 2025
$2.2M
NHLBI NIH HHS R01 HL164350
6 · The paper itself

Abstract

Pulmonary fibrosis (PF) is a severe consequence of respiratory infections, characterized by excessive extracellular matrix deposition and irreversible lung architectural damage. Once considered a rare condition, PF is now increasingly recognized in the wake of viral infections, particularly among survivors of viral-induced acute respiratory distress syndrome (ARDS). The COVID-19 pandemic has highlighted in bold relief the observation that many survivors of severe viral pneumonia do not recover fully but develop chronic fibrotic changes that impair lung function. This review examines the clinical evidence and underlying mechanisms linking viral infections-COVID-19, influenza, and other respiratory viruses-to the onset of pulmonary fibrosis. By probing the mechanisms of cellular injury, immune dysregulation, and aberrant repair mechanisms, we aim to illuminate the pathways that transform an acute viral insult into a chronic, fibrotic disease.

Indexed as

COVID-19Influenza, HumanPulmonary FibrosisAnimalsHumansLungRespiratory Distress SyndromeSARS-CoV-2COVIDimmune-mesenchymal cross talkinterstitial lung diseasepost-viral immune dysregulationpulmonary fibrosis

Identifiers

PMID40983473
PMCPMC12871857

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.